NAD+ booster - What does Nicotinamide Mononucleotide (NMN) do

 

About Nicotinamide Mononucleotide 

Nicotinamide Mononucleotide (NMN) is a naturally occurring metabolite that can be found in small amounts in the human body and is found in small amounts in some foods. NMN has been found to be orally bioavailable, and to support NAD+ levels within liver and muscle tissue.

 

Nicotinamide Mononucleotide or NMN is a precursor to Nicotinamide Adenine Dinucleotide or NAD+. In simple words, NMN is the compound that converts into NAD+ through a series of chemical reactions that happen inside the cells. NAD+, on the other hand, is considered crucial for the body as it performs several key tasks, including balancing the body’s circadian rhythm, breaking down nutrients to release cellular energy, and facilitating key enzymatic reactions, some of which delay aging.

 

Recent research has suggested that NMN may support healthy heart function, bodily energy production, brain health, and well as eye and bone health. One of the most exciting findings of NMN research is that it may support DNA repair and promote the SIRTUIN genes which are believed to play a role in healthy aging.

What is Nicotinamide Mononucleotide (NMN) use for?

In preclinical studies, Nicotinamide Mononucleotide (NMN) work on mice has proved to be handy in cellular biochemical activities, management of Alzheimer’s disease, age-related diabetes, complications that arise from obesity, and cardioprotection. Despite all these pharmacological activities associated with Nicotinamide Mononucleotide, the most groundbreaking discovery is its involvement in anti-aging activities.

 

With old age, the body uses up more NAD+ than it can manufacture. Choosing to supplement with NMN along with NAD provides a much more direct path to promoting cell metabolism and is thus a much quicker means of doing the same. In addition, NMN has been found to improve insulin activity and production, resulting in additional metabolic benefits as well as glucose tolerance. In particular, NMN supplements can help work to alleviate metabolic conditions like diabetes, fatty liver disease, and obesity.

 

By taking NMN supplements, you may also reap benefits that include:

 

• NMN boosts energy supply in aging cells
• NMN helps in fighting metabolic diseases
• NMN Boosts cognition
• Can get Healthier liver and metabolism
• Longer lifespan
• Improved blood flow and nutrient delivery to cells
• Enhanced endurance

How is NMN Synthesized In the Body?

NMN is produced from B vitamins in the body. The enzyme responsible for making NMN in the body is called nicotinamide phosphoribosyltransferase (NAMPT).  NAMPT attaches  nicotinamide (a vitamin B3) to a sugar phosphate called PRPP (5’-phosphoribosyl-1-pyrophosphate). NMN can also be made from ‘nicotinamide riboside’ (NR) through the addition of a phosphate group.

 

‘NAMPT’ is the rate-limiting enzyme in the production of NAD+. This means lower levels of NAMPT cause decreased NMN production, resulting in decreased NAD+ levels. Adding precursor molecules like NMN can also speed up NAD+ production.

 

Does NMN make you younger?

Overall, the most important aspect of NMN promoting longevity is it’s ability to promote NAD+ levels and thereby Sirtuin function. NAD+ is the fuel that helps sirtuins sustain genome integrity and promote DNA repair. Results from animal studies showed that raising NAD+ level in the body activates sirtuins and increases the lifespans of yeast, worms and mice.

 

NAD+ levels decline as we age, and thereby any function in our body that is being supported by NAD+ may not work as well. By replenishing our bodies with NAD+ by taking an NMN supplement, we can help support these vital processes that rely on adequate NAD+ levels.

 

To increase NMN natrually - What food contain NMN ?

 

NMN occurs naturally in various foods. The highest amounts are found in edamame, broccoli, cucumber, and cabbage. Moderate amounts are present in avocado and tomato. Smaller amounts show up in raw beef, shrimp, cow milk, and human breast milk. Because of a the low levels of NMN in these foods, NMN supplements may be a more effective way to increase levels.

 

How long does it for take NMN to work?

 

NMN appears to be absorbed into cells through a molecular transporter embedded in the cell surface. Being smaller than NAD+, the NMN molecule may be absorbed more efficiently into cells. NAD+ cannot easily enter the body because of the barrier presented by the cell membrane. The membrane has a waterless space which  prevents ions, polar molecules, and large molecules from entering without the use of transporters. It was once thought that NMN must be altered before entering cells but new evidence suggests that it can enter cells directly via an NMN-specific transporter in the cellular membrane.

 

Furthermore, injections of NMN result in increased NAD+ in many regions in the body including the pancreas, fat tissue, the heart, skeletal muscle, kidneys, testes, eyes, and blood vessels. Oral administration of NMN in mice increases NAD+ in the liver within 15 minutes.

 

Should you take NMN with foods

We recommend you take NMN on an empty stomach first thing in the morning even if you’re fasting. Don’t mix the sublingual NMN with juice or water, it will reduce the bioavailability.

 

Nicotinamide Mononucleotide (NMN) side effects - Is it safe to use NMN?

So far, in all the available Nicotinamide Mononucleotide work on mice, no data shows the existence of any side effects in murine models. No researcher has recorded a negative symptom both in short and long-term NMN administration.

 

The studies showed that the single oral administrations of NMN 100, 250 and 500mg did not cause any significant clinical symptoms or changes in main biomarkers like heart rate, blood pressure, oxygen saturation, and body temperature. The trial helps to confirm that, in general, NMN is safe and well-tolerated.

 

It’s very important to always store your NMN powder in a cool climate or ideally in a fridge. If you notice symptoms of reduced effectiveness of NMN such as decreased sleep quality and reduced memory, it might be beneficial to cycle off NMN for one week to allow the body the occasional break.

 

How to select high quality NMN supplement?

 

Choose pure NMN

The cheaper options of NMN, that are currently on the market, may well contain contaminants. In fact, there is sometimes less than 10% NMN in food-grade NMN. Phcoker guarantee NMN purity is no less than 98%.

 

Beware of lower prices than the norm

 

Another sign that a product is fake, is the price. If you find a product that is double the weight and half of the price of most other NMN products, chances are the provider is either using fillers or a fake product. There should be a warning bell that goes off if the price is way cheaper than its competitors.

 

Ask for third-party lab reports

 

Any supplement company that offers high-quality supplements should have them tested by a third party. This includes purity, contaminants, and heavy metals. As a customer, you should be able to request to see these reports. If they refuse to give them to you, it may be a sign that the product is a fake.

 

At phcoker.com, we know you only want the best for your body. We want that too and so we never compromise when it comes to quality. Phcoker provide 99% food grade NMN raw powder. Our powders contain no binders, fillers, excipients, dyes, or unknown substances. All our products are tested to ensure that they are of the highest standard. You can ask us for the COA reports at any time.

 

Reference:

 

[1] Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism. Hong W, Mo F, Zhang Z, Huang M, Wei X. Front Cell Dev Biol. 2020 Apr 28;8:246. doi: 10.3389/fcell.2020.00246. eCollection 2020.

[2] Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Cell Metab. 2016 Dec 13;24(6):795-806. doi: 10.1016/j.cmet.2016.09.013. Epub 2016 Oct 27.

[3] Multi-targeted Effect of Nicotinamide Mononucleotide on Brain Bioenergetic Metabolism. Klimova N, Kristian T. Neurochem Res. 2019 Oct;44(10):2280-2287. doi: 10.1007/s11064-019-02729-0. Epub 2019 Jan 19.

[4] [Aging and homeostasis. Age-associated diseases and clinical application of NMN(Nicotinamide Mononucleotide).]. Irie J, Itoh H.Clin Calcium. 2017;27(7):983-990.

[5] Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, Yamashita K, Shigaki S, Ono T, Yukioka H, Okano H, Nabeshima YI, Imai SI, Yasui M, Tsubota K, Itoh H.Endocr J. 2020 Feb 28;67(2):153-160. doi: 10.1507/endocrj.EJ19-0313. Epub 2019 Nov 2.

[6] Subacute Toxicity Study of Nicotinamide Mononucleotide via Oral Administration. You Y, Gao Y, Wang H, Li J, Zhang X, Zhu Z, Liu N. Front Pharmacol. 2020 Dec 15;11:604404. doi: 10.3389/fphar.2020.604404. eCollection 2020.

[7] Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S, Sadoshima J. PLoS One. 2014 Jun 6;9(6):e98972. doi: 10.1371/journal.pone.0098972. eCollection 2014.